La vitamina D è associata a molteplici funzioni e malattie del corpo umano
La vitamina D aiuta a combattere i virus
La vitamina D aumenta l’immunità umorale e sopprime le tempeste di citochine
La vitamina D può aiutare ad aumentare la produzione di anticorpi e quindi a regolare una tempesta di citochine.
I livelli di vitamina D sono associati a esiti avversi nei pazienti COVID-19
Riferimento
Studio in ospedale: per valutare l’importanza di livelli di vitamina D sufficienti nella gestione del COVID-19.
Materiale e metodo: uno studio di coorte prospettico condotto presso la Mamata Academy of medical sciences in cui 170 pazienti sono stati divisi in 3 gruppi in base ai livelli di vitamina D. Per la misurazione dei livelli di vitamina D sono state utilizzate apparecchiature Mindray CL1000i e i kit CLIA.
Livelli di vitamina D e classificazione: <20 ng/ml —— Carenza; 20-30 ng/ml —— Insufficienza; 30-100 ng/ml —— Normale
Risultati
Tabella 1. Statistiche di livelli di vitamina D suddivisi per sesso
Categoria vitamina D | Maschio | Femmina | Total |
Carenza | 84 | 51 | 135 |
Insufficienza | 14 | 9 | 23 |
Normale | 07 | 02 | 09 |
Tabella 2. Dettagli della degenza ospedaliera rispetto alla norma
Categoria | 0-5 giorni | 5-10 giorni | >10 giorni |
Carenza | 36 | 84 | 14 |
Insufficienza | 09 | 10 | 04 |
Normale | 06 | 02 | 01 |
Tabella 3. Natura della malattia in base alla condizione respiratoria
Categoria | Nessun fabbisogno di ossigeno (lieve) | Fabbisogno di O2 continuo (moderata) | Ossigenazione nasale ad alto flusso (grave) | Ventilatore (molto grave) | Mortalità |
Carenza | 22 | 82 | 24 | 08 | 01 |
Insufficienza | 07 | 11 | 04 | 02 | 00 |
Normale | 06 | 02 | 01 | 00 | 00 |
Riferimenti
[1] Jeon, S. M., & Shin, E. A. (2018). Exploring vitamin D metabolism and function in cancer. Experimental & molecular medicine, 50(4), 1-14.Riferimenti
[2] Roth, D. E., Abrams, S. A., Aloia, J., Bergeron, G., Bourassa, M. W., Brown, K. H., … & Whiting, S. J. (2018). Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low-and middle-income countries. Annals of the New York Academy of Sciences, 1430(1), 44.
[3] Charoenngam, N., & Holick, M. F. (2020). Immunologic effects of vitamin D on human health and disease. Nutrients, 12(7), 2097.
[4] Skrobot, A., Demkow, U., & Wachowska, M. (2018). Immunomodulatory role of vitamin D: a review. Current Trends in Immunity and Respiratory Infections, 13-23.
[5] Hollis, B. W., & Wagner, C. L. (2017). New insights into the vitamin D requirements during pregnancy. Bone research, 5(1), 1-16.
[6] Hathcock, J. N., Shao, A., Vieth, R., & Heaney, R. (2007). Risk assessment for vitamin D. The American journal of clinical nutrition, 85(1), 6-18.
[7] Halfon, M., Phan, O., & Teta, D. (2015). Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty. BioMed research international, 2015.
[8] Holick, M. F. (2015). Vitamin D and brain health: the need for vitamin D supplementation and sensible sun exposure. Artaza, J. N., Mehrotra, R., & Norris, K. C. (2009). Vitamin D and the cardiovascular system. Clinical Journal of the American Society of Nephrology, 4(9), 1515-1522.
[9] Amrein, K., Scherkl, M., Hoffmann, M., Neuwersch-Sommeregger, S., Köstenberger, M., Berisha, A. T., … & Malle, O. (2020). Vitamin D deficiency 2.0: an update on the current status worldwide. European journal of clinical nutrition, 74(11), 1498-1513.
[10] Kennel, K. A., Drake, M. T., & Hurley, D. L. (2010, August). Vitamin D deficiency in adults: when to test and how to treat. In Mayo Clinic Proceedings (Vol. 85, No. 8, pp. 752-758). Elsevier.
[11] Radujkovic, A., Hippchen, T., Tiwari-Heckler, S., Dreher, S., Boxberger, M., & Merle, U. (2020). Vitamin D deficiency and outcome of COVID-19 patients. Nutrients, 12(9), 2757.
[12] D’Avolio, A., Avataneo, V., Manca, A., Cusato, J., De Nicolò, A., Lucchini, R., … & Cantù, M. (2020). 25-Hydroxyvitamin D concentrations are lower in patients with positive PCR for SARS-CoV-2. Nutrients, 12(5), 1359.
[13] Jain, A., Chaurasia, R., Sengar, N. S., Singh, M., Mahor, S., & Narain, S. (2020). Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Scientific reports, 10(1), 1-8.
[14] Daneshkhah, A., Agrawal, V., Eshein, A., Subramanian, H., Roy, H. K., & Backman, V. (2020). Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients. Aging Clinical and Experimental Research, 32(10), 2141-2158.
[15] Merzon, E., Tworowski, D., Gorohovski, A., Vinker, S., Golan Cohen, A., Green, I., & Frenkel‐Morgenstern, M. (2020). Low plasma 25 (OH) vitamin D level is associated with increased risk of COVID‐19 infection: an Israeli population‐based study. The FEBS journal, 287(17), 3693-3702.
[16] Martineau, A. R., Jolliffe, D. A., Hooper, R. L., Greenberg, L., Aloia, J. F., Bergman, P., … & Camargo, C. A. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. bmj, 356.
[17] Keshav Kumar, T Venkataramana Reddy, Reddy Jayaprakash Reddy, Ravi Ranjan Verma, & Dharmpal Sharma. (2021). Vitamin D levels in COVID-19 patients at tertiary care center and its significance-An hospital based study. International journal of scientific research, 10(1), 2277 – 8179.